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isoniazid will increase the stage or effect of pazopanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Prevent coadministration of pazopanib with strong CYP3A4 inhibitors if possible; if need to coadminister, reduce pazopanib dose to 400 mg/dayWestern blotting Assessment illustrated that ARV-825 displayed effective
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